Acetaldehyde → 4-[5-(3-Methoxy-phenyl)-thiazol-2-ylamino]-phenol

HRID 1713650

Reaction equation

HRID 1713650 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]2[S:11][C:12]([C:15]3[CH:20]=[CH:19][C:18](OC)=[CH:17][CH:16]=3)=[CH:13][N:14]=2)=[CH:5][CH:4]=1.[OH:23][C:24]1C=CC(NC(N)=S)=CC=1.C(=O)C>C(Cl)Cl.CO>[CH3:24][O:23][C:19]1[CH:20]=[C:15]([C:12]2[S:11][C:10]([NH:9][C:6]3[CH:5]=[CH:4][C:3]([OH:2])=[CH:8][CH:7]=3)=[N:14][CH:13]=2)[CH:16]=[CH:17][CH:18]=1

Participants

5

Reactant 3

HCID 177AcetaldehydeHCID 2759331p-HydroxyphenylthioureaHCID 11266955(4-Methoxy-phenyl)-[5-(4-methoxy-phenyl)thiazol-2-yl]-amine

Product 1

HCID 113584484-[5-(3-Methoxy-phenyl)-thiazol-2-ylamino]-phenol

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 4 for (4-methoxy-phenyl)-[5-(4-methoxy-phenyl)-thiazol-2-yl]-amine but using (4-hydroxy-phenyl)-thiourea and 3-methoxy-phenyl)-acetaldehyde. Title compound: ES-MS: 312.9 [M−H]−; single peak at tR=6.81 min (System 1); Rf=0.28 (CH2Cl2/MeOH, 95/5).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-095c54be9d7b487eb22ce7533448e967
Source dataset
uspto-grants-2010_09
Patent number
US07795288B2

Linked notes

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