Triethyl phosphonoacetate → Ethyl 3-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]acrylate

HRID 1714586Notes

Reaction equation

HRID 1714586 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([S:15][C:16]2[CH:23]=[CH:22][C:19]([CH:20]=O)=[C:18]([Cl:24])[CH:17]=2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OP([CH2:33][C:34]([O:36][CH2:37][CH3:38])=[O:35])(OCC)=O)C>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([S:15][C:16]2[CH:23]=[CH:22][C:19]([CH:20]=[CH:33][C:34]([O:36][CH2:37][CH3:38])=[O:35])=[C:18]([Cl:24])[CH:17]=2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 13345Triethyl phosphonoacetateHCID 166554054-(3-Benzyloxyphenylthio)-2-chlorobenzaldehyde

Product 1

HCID 59464778Ethyl 3-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]acrylate

Procedure

reacting 4-(3-benzyloxyphenylthio)-2-chlorobenzaldehyde with ethyl diethylphosphonoacetate in a solvent in the presence of a base to form ethyl 3-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]acrylate;

Sources & evidence

ORD record
ord-b550a8f87fd54247a6c1f2863331d549
Source dataset
uspto-grants-2010_09
Patent number
US07795472B2

Reaction notes

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