Ammonia → N-(2,2-Dimethoxyethyl)thiourea
Reaction equation
[NH3:1].[CH3:2][O:3][CH:4]([O:9][CH3:10])[CH2:5][N:6]=[C:7]=[S:8]>CO>[CH3:2][O:3][CH:4]([O:9][CH3:10])[CH2:5][NH:6][C:7]([NH2:1])=[S:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Methanol (200 mL) was saturated with ammonia and stirred with isothiocyanatoacetaldehyde dimethyl acetal (5.0 g) for 2 h. The mixture was concentrated and the residue was chromatographed (silica gel, 5% methanol/dichloromethane) to give the title compound.
Workup
- concentrationThe mixture was concentrated
- customthe residue was chromatographed (silica gel, 5% methanol/dichloromethane)
Sources & evidence
- ORD record
- ord-37d4e94f18a64572955158f797a738e8
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05726192
Reaction notes
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