ethyl 4-bromo-3-methoxy-1H-indazole-1-carboxylate → 5-Bromo-3-methoxy-indazole-1-carboxylic acid ethyl ester

Reaction equation

[CH2:1]([O:3][C:4]([N:6]1[C:14]2[C:9](=[CH:10][C:11]([Br:15])=[CH:12][CH:13]=2)[C:8]([OH:16])=[N:7]1)=[O:5])[CH3:2].[CH2:17](OC(N1C2C(=C(Br)C=CC=2)C(OC)=N1)=O)C>>[CH2:1]([O:3][C:4]([N:6]1[C:14]2[C:9](=[CH:10][C:11]([Br:15])=[CH:12][CH:13]=2)[C:8]([O:16][CH3:17])=[N:7]1)=[O:5])[CH3:2]

Participants

Reactant 2

HCID 59831716ethyl 4-bromo-3-methoxy-1H-indazole-1-carboxylate

HCID 178473414HCID 178473414, compound

Product 1

HCID 598316165-Bromo-3-methoxy-indazole-1-carboxylic acid ethyl ester

Procedure

5-Bromo-3-methoxy-indazole-1-carboxylic acid ethyl ester CCIX was prepared from 5-bromo-3-hydroxy-indazole-1-carboxylic acid ethyl ester using the procedure described for preparation of 4-Bromo-3-methoxy-indazole-1-carboxylic acid ethyl ester CLXXXV (Example 37).

Sources & evidence

ORD record: ord-ca0d3f6fb0b74a4c87565c92eeb279f8
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07803830B2

Reaction notes

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