Ammonia → 4,6-Bis(difluoromethoxy)pyrimidin-2-amine
Reaction equation
[F:1][CH:2]([F:18])[O:3][C:4]1[CH:9]=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]=[C:6](S(C)(=O)=O)[N:5]=1.[NH3:19]>C(Cl)Cl>[F:1][CH:2]([F:18])[O:3][C:4]1[CH:9]=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]=[C:6]([NH2:19])[N:5]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 1.0 g of 4,6-bis(difluoromethoxy)-2-methylsulfonylpyrimidine in 20 ml of methylene chloride are added, with vigorous stirring, 5 ml of a 30% aqueous ammonia solution, in the course of which the reaction mixture warms up and is stirred for a further 2 hours. The solution is subsequently concentrated by evaporation and crystallised to thus obtain, in quantitative yield, (0.8 g) 4,6-bis(difluoromethoxy)-2-aminopyrimidine, m.p. 67°-69° C.
Workup
- concentrationThe solution is subsequently concentrated by evaporation
- customcrystallised
Sources & evidence
- ORD record
- ord-f363504391a647df890474337d5414c1
- Source dataset
- uspto-grants-1985_09
- Patent number
- US04542216
Reaction notes
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