Methylhydrazine → N-methylbenzohydrazide
Reaction equation
[CH3:1][NH:2][NH2:3].[C:4](Cl)(=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>ClCCl>[C:4]([N:2]([CH3:1])[NH2:3])(=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Methylhydrazine (0.212 ml, 4.0 mmol) was dissolved in dichloromethane (10 ml) and was treated dropwise with benzoylchloride (0.232 ml, 2.0 mmol) in dichloromethane (5 ml). After stirring for 0.5h the solution was evaporated to dryness. The residue was partitioned between water and ethyl acetate. The organic phase was dried and evaporated under reduced pressure to give the title compound (0.20 g, 65%); δH (CDCl3) 3.13 (3H, s), 4.5 (2H, brs), and 7.30 (5H, s).
Workup
- customwas evaporated to dryness
- customThe residue was partitioned between water and ethyl acetate
- customThe organic phase was dried
- customevaporated under reduced pressure
Sources & evidence
- ORD record
- ord-64901f962b6946c588844917b5af40ea
- Source dataset
- uspto-grants-1996_04
- Patent number
- US05504076
Reaction notes
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