HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6,7-dimethoxy-4-quinazolinamine → Terazosin Hydrochloride Anhydrous
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6,7-dimethoxy-4-quinazolinamine | HCID 90235 | — |
| Reactant | 1-(Tetrahydro-2-furoyl)piperazine | HCID 2734641 | — |
| Product | Terazosin Hydrochloride Anhydrous | HCID 44383 | — |
Reaction Steps
reacting 4-amino-2-chloro-6,7-dimethoxyquinazoline with N-(2-tetrahydrofuroyl)piperzine "in a ratio of 1 to n where n is up to 1.2"in an anhydrous polar organic solvent in the absence of an added acid scavenger to produce the Form IV crystalline modification of anhydrous 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)-piperazine hydrochloride; and
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05504207 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-9387b4b66cde4b7cb5d975b3c60336c1 |
| Source note | uspto-grants-1996_04 |