Atreleuton → Z-(R)-N-[3-(5-(4-chlorophenylmethyl)-thien-2-yl)-1-methyl-2-propenyl]-N-hydroxyurea

HRID 1720443

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]2[S:13][C:12]([C:14]#[C:15][C@H:16]([N:18]([OH:22])[C:19]([NH2:21])=[O:20])[CH3:17])=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.FC1C=CC(CC2SC(C#C[C@H](N(O)C(N)=O)C)=CC=2)=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]2[S:13][C:12](/[CH:14]=[CH:15]\[C@H:16]([N:18]([OH:22])[C:19]([NH2:21])=[O:20])[CH3:17])=[CH:11][CH:10]=2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 3086671Atreleuton

HCID 53890623HCID 53890623, compound

Product 1

HCID 86749397Z-(R)-N-[3-(5-(4-chlorophenylmethyl)-thien-2-yl)-1-methyl-2-propenyl]-N-hydroxyurea

Procedure

The desired compound is prepared according to the method of Example 1, step 5, except substituting (R)-N-{3-[5-(4-chlorophenylmethyl)thien-2-yl]-1-methyl-2-propynyl}-N-hydroxyurea, prepared as in step 4, for (R)-N-{3-[5-(4-fluorophenylmethyl)thien-2-yl]-1-methyl-2-propynyl}-N-hydroxyurea.

Sources & evidence

ORD record: ord-4d46b8df6f64485985d17b128c79e0a1
Source dataset: uspto-grants-1996_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05506261

Linked notes

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