Sodium Hydroxide → 3-(Pyrrolidine-1-carbonyl)thiomorpholine
Reaction equation
[OH-].[Na+].Cl.[N:4]1([C:9]([CH:11]2[CH2:16][S:15][CH2:14][CH2:13][NH:12]2)=[O:10])[CH2:8][CH2:7][CH2:6][CH2:5]1>C(Cl)Cl>[N:4]1([C:9]([CH:11]2[CH2:16][S:15][CH2:14][CH2:13][NH:12]2)=[O:10])[CH2:5][CH2:6][CH2:7][CH2:8]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A 1N aqueous sodium hydroxide solution (12.5 ml) was added to a mixture of 2.47 g of 3-(pyrrolidine1-carbonyl)thiomorpholine monohydrochloride and 20 ml of methylene chloride. The organic layer was extracted and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to yield 1.75 g (83%) of 3-(pyrrolidine-1-carbonyl)thiomorpholine
Workup
- extractionThe organic layer was extracted
- dry with materialdried over anhydrous magnesium sulfate
- customThe solvent was evaporated under reduced pressure
Sources & evidence
- ORD record
- ord-fa22c8d5492641a6bebc2efd43d96aef
- Source dataset
- uspto-grants-1996_04
- Patent number
- US05512567
Reaction notes
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