4-Chloro-2-fluoro-5-isopropoxyphenyl isocyanate → 3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5-fluoro-6-pentafluoroethyl-2,4(1H,3H)-pyrimidinedione
Reaction equation
[NH2:1][C:2]([C:10]([F:16])([F:15])[C:11]([F:14])([F:13])[F:12])=[C:3]([F:9])[C:4]([O:6]CC)=O.[Cl:17][C:18]1[C:23]([O:24][CH:25]([CH3:27])[CH3:26])=[CH:22][C:21]([N:28]=[C:29]=[O:30])=[C:20]([F:31])[CH:19]=1>>[Cl:17][C:18]1[C:23]([O:24][CH:25]([CH3:26])[CH3:27])=[CH:22][C:21]([N:28]2[C:4](=[O:6])[C:3]([F:9])=[C:2]([C:10]([F:15])([F:16])[C:11]([F:12])([F:13])[F:14])[NH:1][C:29]2=[O:30])=[C:20]([F:31])[CH:19]=1Participants
3
Procedure
using ethyl 3-amino-2,4,4,5,5,5-hexafluoro-2-pentenoate and 4-chloro-2-fluoro-5-isopropoxyphenyl isocyanate there is obtained 3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5 -fluoro-6-pentafluoroethyl-2,4(1H,3H)-pyrimidinedione, m.p. 160°-162° C.;
Sources & evidence
- ORD record
- ord-2167faa6904443d98880acaf96e40a3b
- Source dataset
- uspto-grants-1989_08
- DOI