(6-Methoxy-indan-1-ylidene)-acetic acid ethyl ester → Ethyl (6-methoxyindan-1-yl)acetate

HRID 1727052

Reaction equation

HRID 1727052 reaction equation
[CH2:1]([O:3][C:4](=[O:17])[CH:5]=[C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH3:16])[CH:13]=2)[CH2:8][CH2:7]1)[CH3:2]>CO.[Pd]>[CH2:1]([O:3][C:4](=[O:17])[CH2:5][CH:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH3:16])[CH:13]=2)[CH2:8][CH2:7]1)[CH3:2]

Participants

4

Reactant 1

HCID 67045796(6-Methoxy-indan-1-ylidene)-acetic acid ethyl ester

Product 1

HCID 11064342Ethyl (6-methoxyindan-1-yl)acetateYield 94%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

(6-methoxy-indan-1-ylidene)-acetic acid ethyl ester (3.18 g, 14.5 mmol) was dissolved in MeOH (30 ml). A catalytic amount of 10% Pd/C was added and the reaction was stirred under an atmosphere of hydrogen (balloon) for 2 h. The reaction mixture was filtered through Celite to provide pure (6-methoxy-indan-1-yl)-acetic acid ethyl ester (2.98 g, 94%) as a clear oil. LCMS: 235.0 (M+1)+.

Workup

  1. filtrationThe reaction mixture was filtered through Celite

Sources & evidence

ORD record
ord-d7f5be419d42415d83c47cd68fd9d40b
Source dataset
uspto-grants-2009_02
Patent number
US07494999B2

Linked notes

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