Methyl iodide → 7-Bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline

Reaction equation

Cl.[Br:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][NH:9][CH2:10]2)=[CH:5][CH:4]=1.I[CH3:14]>>[Br:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][N:9]([CH3:14])[CH2:10]2)=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 450739697-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride

Product 1

HCID 534084697-Bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline

Procedure

Following the procedure described for Intermediate 3 using 7-bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride and iodomethane provided the title compound. ESMS [M+H]+: 226.0.

Sources & evidence

ORD record: ord-4519eb3e50d246209f908449174afe40
Source dataset: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07495102B2

Reaction notes

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