Sodium Hydroxide → 2-Methyl-3-(2-methylphenyl)propanoic acid
Reaction equation
[CH3:1][CH:2]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH3:14])[C:3]([O:5]C)=[O:4].[OH-].[Na+]>CO>[CH3:1][CH:2]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH3:14])[C:3]([OH:5])=[O:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
38.45 g (200 mmol) of ester f2, 850 ml of 5% strength NaOH and 850 ml of MeOH were refluxed for 4.5 hours, the MeOH was distilled off, the product was acidified, and the ether extract was dried with MgSO4 and distilled (107°-109° C./high vacuum).
Workup
- distillationthe MeOH was distilled off
- extractionthe ether extract
- dry with materialwas dried with MgSO4
- distillationdistilled (107°-109° C./high vacuum)
Sources & evidence
- ORD record
- ord-7155b9fd76d04a2fa249fa932102eaf2
- Source dataset
- uspto-grants-1994_07
- Patent number
- US05329033
Reaction notes
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