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Methanol → Methyl 7-methyl-9H-xanthene-2-carboxylate

HRID 1729737
Notes
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Reaction equation

HRID 1729737 reaction equation
[CH3:1][C:2]1[CH:15]=[C:14]2[C:5]([O:6][C:7]3[CH:8]=[CH:9][C:10]([C:16]([OH:18])=[O:17])=[CH:11][C:12]=3[CH2:13]2)=[CH:4][CH:3]=1.[CH3:19]O.S(=O)(=O)(O)O>O>[CH3:1][C:2]1[CH:15]=[C:14]2[C:5]([O:6][C:7]3[CH:8]=[CH:9][C:10]([C:16]([O:18][CH3:19])=[O:17])=[CH:11][C:12]=3[CH2:13]2)=[CH:4][CH:3]=1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 215006717-Methyl-9H-xanthene-2-carboxylic acid

Product 1

HCID 21500836Methyl 7-methyl-9H-xanthene-2-carboxylate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

Twenty-six grams of 7-methylxanthene-2-carboxylic acid is added to 400 ml. of absolute methanol. To the resultant solution are added 18 ml. of concentrated sulfuric acid and the mixture is then heated at reflux for about 2 hours. The mixture is then cooled to 40° C and sufficient water is added to bring the total volume to 1400 ml. The resultant mixture is then filtered to give methyl 7-methylxanthene-2-carboxylate.

Workup

  1. temperatureat reflux for about 2 hours
  2. filtrationThe resultant mixture is then filtered

Sources & evidence

ORD record
ord-6915eb5641a44c768ed3cc996efda929
Source dataset
uspto-grants-1976_11
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US03989720

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes