Formic Acid → HCID 12408792, compound
Reaction equation
[NH2:1][C:2]1[C:3]([C:16](=[O:23])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:4]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[CH:24](O)=[O:25]>>[C:16]([C:3]1[C:2]([NH:1][CH:24]=[O:25])=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[O:11][CH2:12][CH2:13][CH2:14][CH3:15])(=[O:23])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1Participants
3
Procedure
A solution of 5-amino-4-benzoyl-3-n-butoxybenzoic acid (1.0 g) and formic acid (10 ml) is stirred at room temperature for 24 hours. After cooling, the resulting precipitate is collected and washed with ice-cold formic acid followed by cold water. After drying and recrystallization from ethanol, 4-benzoyl-3-n-butoxy-5-formamidobenzoic acid is obtained with a melting point of 180°-183° C.
Workup
- temperatureAfter cooling
- customthe resulting precipitate is collected
- washwashed with ice-cold formic acid
- customAfter drying
- customrecrystallization from ethanol