Octylamine → 1-Octylazepin-2-one

Reaction equation

[C:1]1(=O)[O:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:9]([NH2:17])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]>>[CH2:9]([N:17]1[CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1=[O:7])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Participants

Reactant 2

HCID 8143Octylamine

HCID 10401epsilon-CAPROLACTONE

Product 1

HCID 27540671-Octylazepin-2-one

Procedure

Alternatively, equimolar amounts of 6-hexanolactone and n-octylamine were heated at 190° for 20 hours. In this time, water was distilled off slowly. The residue was distilled to obtain 1-octyl-azacycloheptan-2-one.

Workup

distillationIn this time, water was distilled off slowly
distillationThe residue was distilled

Sources & evidence

ORD record: ord-7a936a24634443f29bed4aaf9bf9f11a
Source dataset: uspto-grants-1976_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03989816

Reaction notes

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