1-Hydrazinoisoquinoline → 3-Acetoxymethyl-s-triazolo-[3,4-a]-isoquinoline
Reaction equation
[NH:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][N:4]=1)[NH2:2].[C:13]([O:16][CH:17](O)[C:18](O)=O)(=[O:15])[CH3:14]>C(Cl)(Cl)Cl>[C:13]([O:16][CH2:17][C:18]1[N:4]2[CH:5]=[CH:6][C:7]3[C:12]([C:3]2=[N:1][N:2]=1)=[CH:11][CH:10]=[CH:9][CH:8]=3)(=[O:15])[CH3:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
1-Hydrazinoisoquinoline was heated with excess acetoxyglycolic acid. The residue was cooled, dissolved in chloroform and washed with sodium carbonate solution. The chloroform extracts were dried and concentrated invacuo to provide the crude product which was purified by recrystallization from benzene.
Workup
- temperatureThe residue was cooled
- washwashed with sodium carbonate solution
- dry with materialThe chloroform extracts were dried
- concentrationconcentrated invacuo
Sources & evidence
- ORD record
- ord-ec8c70329bf748aa9232107ce1873fb3
- Source dataset
- uspto-grants-1976_11
- Patent number
- US03992539
Reaction notes
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