2-Bromo-5-(chlorosulfonyl)benzoic acid → HCID 20505966, compound
Reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH2:15]([O:22][CH:23]1[CH2:28][CH2:27][CH2:26][NH:25][CH2:24]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([N:25]2[CH2:26][CH2:27][CH2:28][CH:23]([O:22][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:24]2)(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]Participants
3
Procedure
2-Bromo-5-chlorosulfonylbenzoic acid is reacted with 3-benzyloxypiperidine by the method of Example 1. Recrystallization from ether-hexane yields theproduct, m.p. 177°-178° C.
Workup
- customRecrystallization from ether-hexane
- customyields theproduct, m.p. 177°-178° C.
Sources & evidence
- ORD record
- ord-85f6c071ed2e43a486f0db7ec70750c7
- Source dataset
- uspto-grants-1976_11