Sulfuric Acid → HCID 178419078, compound

HRID 1731195Notes

Reaction equation

HRID 1731195 reaction equation
[NH:1]([CH2:5][CH2:6][C:7]([NH:9][C@H:10]([C:17]([OH:19])=[O:18])[CH2:11][C:12]1[N:16]=[CH:15][NH:14][CH:13]=1)=[O:8])[C:2]([NH2:4])=[NH:3].C(SC(=N)N)C.[OH:26]S(O)(=O)=O.NCCC(N[C@H](C(O)=O)CC1N=CNC=1)=O>O>[NH:1]([CH2:5][CH2:6][C:7]([OH:8])=[O:26])[C:2]([NH2:4])=[NH:3].[NH2:9][C@H:10]([C:17]([OH:19])=[O:18])[CH2:11][C:12]1[N:16]=[CH:15][NH:14][CH:13]=1

Participants

7

Reactant 4

HCID 1118Sulfuric AcidHCID 5139S-EthylisothioureaHCID 439224CarnosineHCID 178512995HCID 178512995, compound

Product 2

HCID 178419078HCID 178419078, compoundHCID 178512996HCID 178512996, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To prepare beta-guanidinopropionyl-L-histidine.H2O, (n=2) S-ethylisothiourea.H2SO4 (5.0 g) and βAla-His (5.3 g) were reacted by the procedure described in Example 1: yield, 38.8%; mp, 121°-124° C., decomp. Hydrolysis as described in Example 1 gave beta-guanidinopropionic acid and histidine tlc.

Workup

  1. customyield
  2. customHydrolysis

Sources & evidence

ORD record
ord-a7a774a5e6354ed58ee854c3ee76d7be
Source dataset
uspto-grants-1976_11
Patent number
US03995051

Reaction notes

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