Sulfuric Acid → HCID 178419078, compound

HRID 1731196

Reaction equation

HRID 1731196 reaction equation
[NH:1]([CH:5](C)[CH2:6][CH2:7][CH2:8][C:9]([NH:11][C@H:12]([C:19]([OH:21])=[O:20])[CH2:13][C:14]1[N:18]=[CH:17][NH:16][CH:15]=1)=O)[C:2]([NH2:4])=[NH:3].C(SC(=N)N)C.OS(O)(=O)=O.NCCCCCC(N[C@H]([C:50]([OH:52])=[O:51])CC1N=CNC=1)=O>>[NH:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:50]([OH:52])=[O:51])[C:2]([NH2:4])=[NH:3].[NH2:11][C@H:12]([C:19]([OH:21])=[O:20])[CH2:13][C:14]1[N:18]=[CH:17][NH:16][CH:15]=1

Participants

6

Reactant 4

HCID 1118Sulfuric AcidHCID 5139S-EthylisothioureaHCID 178445247HCID 178445247, compoundHCID 178510992HCID 178510992, compound

Product 2

HCID 178419078HCID 178419078, compoundHCID 178512818HCID 178512818, compound

Procedure

ε-Guanidinohexanoyl-L-histidine (n=5) -- S-Ethylisothiourea. H2SO4 (1.4 g.) and εAhx-His (1.7 g.) were treated in the same way as Example 2; yield, 56.1%; mp, 102°-103° C., decomp. Hydrolysis as above gave ε-guanidinohexanoic acid and histidine (tlc).

Workup

  1. customyield
  2. customHydrolysis as

Sources & evidence

ORD record
ord-b44a8425f3054d5a8261480ffd0bcb46
Source dataset
uspto-grants-1976_11
Patent number
US03995051

Linked notes

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