2-Aminopyrimidine → 5-(Imidazo[1,2-a]pyrimidin-2-yl)-3-methyl-2-benzothiazolinone

Reaction equation

Br[CH2:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]2[S:12][C:11](=[O:13])[N:10]([CH3:14])[C:9]=2[CH:15]=1)=O.[NH2:16][C:17]1[N:22]=[CH:21][CH:20]=[CH:19][N:18]=1>>[N:16]1[C:3]([C:5]2[CH:6]=[CH:7][C:8]3[S:12][C:11](=[O:13])[N:10]([CH3:14])[C:9]=3[CH:15]=2)=[CH:2][N:18]2[CH:19]=[CH:20][CH:21]=[N:22][C:17]=12

Participants

Reactant 2

HCID 79782-Aminopyrimidine

HCID 202286755-(Bromoacetyl)-3-methyl-1,3-benzothiazol-2(3H)-one

Product 1

HCID 202286875-(Imidazo[1,2-a]pyrimidin-2-yl)-3-methyl-2-benzothiazolinoneYield 47.8%

Procedure

5-(Imidazo[1,2-a]pyrimidin-2-yl)-3-methyl-2-benzothiazolinone (2.7 g) was prepared in substantially the same manner as that of Example 30 from 5-(2-bromoacetyl)-3-methyl-2-benzothiazolinone (5.72 g) and 2-aminopyrimidine (5.7 g).

Sources & evidence

ORD record: ord-e04a1676918c4065b57928605d732177
Source dataset: uspto-grants-1986_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04621084

Reaction notes

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