Ammonia → Acrylamide, N-cyclohexyl-

HRID 1732224

Reaction equation

HRID 1732224 reaction equation
O[CH2:2][CH2:3][C:4]([NH2:6])=[O:5].[CH:7]1(N)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1.N>>[CH:7]1([NH:6][C:4](=[O:5])[CH:3]=[CH2:2])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 7965CyclohexylamineHCID 41451403-Hydroxypropanamide

Product 1

HCID 137811Acrylamide, N-cyclohexyl-

Conditions

Temperature
164 °C

Procedure

59 g of β-hydroxypropionamide and 69.4 g of cyclohexylamine were heated with 50 mg of 2,6-di-t-butyl-pcresol for 5 hours in a temperature range of 130°-170° C. until the evolution of ammonia was complete. After adding 2.5 g of polyphosphoric acid the reaction mixture was maintained at 164° C. for 1 hour and then distilled in a water jet vacuum. The main run was taken off between 140° and 160° C. at 11 bar and crystallized in the receiver.

Workup

  1. distillationdistilled in a water jet vacuum
  2. customwas taken off between 140° and 160° C. at 11 bar
  3. customcrystallized in the receiver

Sources & evidence

ORD record
ord-2affe934e98d48669833c62c048622d8
Source dataset
uspto-grants-1980_12
Patent number
US04237067

Linked notes

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