5-Chloro-2-methoxybenzoyl chloride → HCID 20304389, compound
Reaction equation
Cl.[NH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][C:12]([O:14]CC)=[O:13])=[CH:6][CH:5]=1.[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([O:27][CH3:28])=[C:22]([CH:26]=1)[C:23](Cl)=[O:24]>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([O:27][CH3:28])=[C:22]([CH:26]=1)[C:23]([NH:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:8][CH:9]=1)=[O:24]Participants
3
Procedure
By reaction of ethyl β-[4-(aminomethyl)-phenyl]-propionate hydrochloride (m.p. 192°-193° C.) with 5-chloro-2-methoxybenzoyl chloride, there is obtained β-[4-(5-chloro-2-methoxybenzamidomethyl)-phenyl]-propionic acid; m.p. 152°-153° C., after recrystallization from isopropanol.
Sources & evidence
- ORD record
- ord-5b3809bb76ab462f8df9762737cf5c53
- Source dataset
- uspto-grants-1980_12