Sulfuryl chloride → (3-Hydroxy-thiophen-2-yl)-phenyl-methanone

Reaction equation

[OH:1][CH:2]1[CH:6]=[CH:5][S:4][CH:3]1[C:7](=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.S(Cl)(Cl)(=O)=O>>[OH:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7](=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 24648Sulfuryl chloride

HCID 20300160HCID 20300160, compound

Product 1

HCID 135542479(3-Hydroxy-thiophen-2-yl)-phenyl-methanoneYield 82%

Procedure

The compound is prepared by the method described in Example 14(c) from 20.6 parts of 3-hydroxy-2-benzoyldihydrothiophene and 6.75 parts of sulfuryl chloride. 16.7 parts (82% of theory) of 3-hydroxy-2-benzoylthiophene of boiling point 127°-132° C./0.5 mbar and melting point 53°-57° C. are obtained.

Workup

customThe compound is prepared by the method

Sources & evidence

ORD record: ord-caeb069510d543c78909a57084e8be07
Source dataset: uspto-grants-1980_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04242518

Reaction notes

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