Water → HCID 21471814, compound
Reaction equation
[S:1]1[C:5]2[CH2:6][NH:7][CH2:8][CH2:9][CH2:10][C:4]=2[CH:3]=[CH:2]1.N1C=CC=CC=1.[C:17](OC(=O)C)(=[O:19])[CH3:18].O>C(Cl)(Cl)Cl>[C:17]([N:7]1[CH2:8][CH2:9][CH2:10][C:4]2[CH:3]=[CH:2][S:1][C:5]=2[CH2:6]1)(=[O:19])[CH3:18]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
To a mixture of 4 g of 5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine and 4 g of pyridine in 20 ml of chloroform was added 4.1 g of acetic anhydride under ice-cooling and the mixture was stirred at room temperature for an hour. The mixture was poured into water and extracted with chloroform. The extract was washed with water, dried and concentrated to give 4 g of 7-acetyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine as an oil.
Workup
- temperaturecooling
- extractionextracted with chloroform
- washThe extract was washed with water
- customdried
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-49249ce58a8e425392a583ab3b9cd281
- Source dataset
- uspto-grants-1996_07
- Patent number
- US05532240
Reaction notes
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