4-Hydroxybenzyl Alcohol → HCID 178447919, compound

HRID 1735376

Reaction equation

HRID 1735376 reaction equation
[F:1][CH:2]([F:13])[O:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1.C1C(CO)=CC=C(O)C=1.[Mn]([O-])(=O)(=O)=O.[K+].[CH2:29]([C@H:32]1[CH2:37][CH2:36][C@H:35]([C:38]2[CH:43]=[CH:42][C:41](O)=[CH:40][CH:39]=2)[CH2:34][CH2:33]1)[CH2:30][CH3:31].C1CCC(N=C=NC2CCCCC2)CC1>>[F:1][CH:2]([F:13])[O:3][C:4]1[CH:5]=[CH:6][C:7]([C:8]([O:10][C:41]2[CH:40]=[CH:39][C:38]([C@H:35]3[CH2:36][CH2:37][C@H:32]([CH2:29][CH2:30][CH3:31])[CH2:33][CH2:34]3)=[CH:43][CH:42]=2)=[O:9])=[CH:11][CH:12]=1

Participants

6

Reactant 5

HCID 1254-Hydroxybenzyl AlcoholHCID 10868DicyclohexylcarbodiimideHCID 516875Potassium PermanganateHCID 7373604-(Difluoromethoxy)benzoic acidHCID 178447901HCID 178447901, compound

Product 1

HCID 178447919HCID 178447919, compound

Procedure

4-Difluoromethoxybenzoic acid (available by etherification of the phenolic OH group of p-hydroxybenzyl alcohol analogously to Example 1a), followed by oxidation with potassium permanganate) is esterified, as described in Example 5b), with 4-(trans-4-propylcyclohexyl)-phenol by the DCC method. m.p.: 104° C., c.p.: 193.5° C.

Workup

  1. custom193.5° C.

Sources & evidence

ORD record
ord-e950a02c81234aa7bab72eb305b3fbc6
Source dataset
uspto-grants-1996_07
Patent number
US05536442

Linked notes

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