Sodium Hydroxide → HCID 19434849, compound
Reaction equation
C([N:4]([C:15]1[CH:20]=[CH:19][C:18]([C:21]2[O:22][C:23]3[C:31]([F:32])=[CH:30][C:29]([F:33])=[C:28]([NH2:34])[C:24]=3[C:25](=[O:27])[CH:26]=2)=[CH:17][C:16]=1[F:35])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12]CC)=[O:11])(=O)C.[OH-].[Na+]>C(O)C>[NH2:34][C:28]1[C:24]2[C:25](=[O:27])[CH:26]=[C:21]([C:18]3[CH:19]=[CH:20][C:15]([NH:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[C:16]([F:35])[CH:17]=3)[O:22][C:23]=2[C:31]([F:32])=[CH:30][C:29]=1[F:33]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
367 mg (0.818 mmol) of Compound 56 obtained in Example 56 was dissolved in 10 ml of ethanol, 1.23 ml of a 2N aqueous solution of sodium hydroxide was added and the mixture was stirred at room temperature for 17 hours. The precipitated crystals were collected by filtration to give 261 mg (69%) of Compound 57.