1,1-Dichloroethane → 3-Cyclohexyl-1-(2,6-dichloro-4-hydroxy-benzyl)-pyrrolidin-2-one

Reaction equation

[B:24]([Br:25])([Br:26])[Br:27].[CH:1]1([CH:7]2[C:8](=[O:23])[N:9]([CH2:12][c:13]3[c:14]([Cl:22])[cH:15][c:16]([O:20][CH3:21])[cH:17][c:18]3[Cl:19])[CH2:10][CH2:11]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1.[Cl:28][CH:29]([Cl:30])[CH3:31]>>[CH:1]1([CH:7]2[C:8](=[O:23])[N:9]([CH2:12][c:13]3[c:14]([Cl:22])[cH:15][c:16]([OH:20])[cH:17][c:18]3[Cl:19])[CH2:10][CH2:11]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

Reactant 3

HCID 63651,1-Dichloroethane

HCID 25134Boron tribromide

HCID 576580123-Cyclohexyl-1-(2,6-dichloro-4-methoxy-benzyl)-pyrrolidin-2-one

Product 1

HCID 576579983-Cyclohexyl-1-(2,6-dichloro-4-hydroxy-benzyl)-pyrrolidin-2-one

Sources & evidence

ORD record: ord-3690d23ad55e4fa38fd1caf5f48f6249
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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