Acetic Acid → 5'-methylspiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Reaction equation

[CH3:39][C:40](=[O:41])[OH:42].[OH-:36].[OH-:38].[Pd+2:37].[c:1]1([CH:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:30]2)[N:8]2[C:9](=[O:29])[C:10]3([CH2:11][O:12][c:13]4[c:14]3[cH:15][c:16]3[c:17]([cH:21]4)[O:18][CH2:19][O:20]3)[c:22]3[cH:23][c:24]([CH3:28])[cH:25][cH:26][c:27]32)[cH:31][cH:32][cH:33][cH:34][cH:35]1>>[NH:8]1[C:9](=[O:29])[C:10]2([CH2:11][O:12][c:13]3[c:14]2[cH:15][c:16]2[c:17]([cH:21]3)[O:18][CH2:19][O:20]2)[c:22]2[cH:23][c:24]([CH3:28])[cH:25][cH:26][c:27]21

Participants

Reactant 4

HCID 176Acetic Acid

HCID 961Hydroxide2×

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 59263474(diphenylmethyl)-5'-methylspiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Product 1

HCID 592634415'-methylspiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record: ord-27b3f22a253b4217a8ae1169ae678f08
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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