Chloroacetone → 1-(3-Ethyl-1-benzofuran-2-yl)ethanone
Reaction equation
O[CH:2]([CH3:11])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.Cl[CH2:13][C:14](=[O:16])[CH3:15].[OH-:17].[K+]>C(O)C>[C:14]([C:13]1[O:17][C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[C:3]=1[CH2:2][CH3:11])(=[O:16])[CH3:15]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Reaction of hydroxypropiophenone (II) with chloroacetone (III) using potassium hydroxide in ethanol gives, by Stroemer-Schaefer condensation, 2-acetyl-3-ethylbenzofuran (IVj, R1 -R4 =H, R5 =C2H5, R6 =CH3) in a yield of about 80% (Belgian Patent Specification 553 621; (Chem. Abs. 5, 22016)).
Sources & evidence
- ORD record
- ord-bc65c71016fb46ccafd861828f1cb05a
- Source dataset
- uspto-grants-1999_10
- Patent number
- US05972878
Reaction notes
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