Potassium Hydroxide → 1-Isopropylpiperazine
Reaction equation
C([N:4]1[CH2:9][CH2:8][N:7]([CH:10]([CH3:12])[CH3:11])[CH2:6][CH2:5]1)(=O)C.[OH-].[K+]>CO>[CH:10]([N:7]1[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]1)([CH3:12])[CH3:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 7.26 g of 1-acetyl-4-isopropylpiperazine, 100 ml of methanol and 10 g of potassium hydroxide was heated under reflux for 17 hours. After the solvent was distilled off, water and chloroform were added to perform extraction with chloroform and the extract was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to afford 5.78 g of the title compound as an oily substance.
Workup
- temperaturewas heated
- temperatureunder reflux for 17 hours
- distillationAfter the solvent was distilled off
- additionwater and chloroform were added
- extractionextraction with chloroform
- dry with materialthe extract was dried over anhydrous magnesium sulfate
- distillationThe solvent was distilled off under reduced pressure
Sources & evidence
- ORD record
- ord-93506c81b4994fe99c541d2a852aa260
- Source dataset
- uspto-grants-1999_10
- Patent number
- US05972943
Reaction notes
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