Isopropyl iodide → 4-Methyl-6-(2-methylpropyl)-2-(2,5-dimethylpyrrol-1-yl)pyridine

HRID 1740984

Reaction equation

[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([N:9]2[C:13]([CH3:14])=[CH:12][CH:11]=[C:10]2[CH3:15])[CH:3]=1.I[CH:17]([CH3:19])[CH3:18]>>[CH3:1][C:2]1[CH:7]=[C:6]([CH2:8][CH:17]([CH3:19])[CH3:18])[N:5]=[C:4]([N:9]2[C:13]([CH3:14])=[CH:12][CH:11]=[C:10]2[CH3:15])[CH:3]=1

Participants

Reactant 2

HCID 6362Isopropyl iodide

HCID 224907362-(2,5-Dimethyl-1H-pyrrol-1-yl)-4,6-dimethylpyridine

Product 1

HCID 218344234-Methyl-6-(2-methylpropyl)-2-(2,5-dimethylpyrrol-1-yl)pyridine

Procedure

By analogy to Example 71, Step A, the anion of 4,6-dimethyl-2-(2,5-dimethylpyrrol-1-yl)pyridine was alkylated with 2-iodopropane to give 4-methyl-6-(2-methylpropyl)-2-(2,5-dimethylpyrrol-1-yl)pyridine.

Sources & evidence

ORD record: ord-b6e44edf110c4c67b4640b68d7d33679
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05972975

Linked notes

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