2-(2-Amino-ethyl)-phenylamine → 8-Amino-4-[2-(2-amino-phenyl)-ethylamino]-quinoline-3-carboxylic acid ethyl ester

HRID 1743318

Reaction equation

HRID 1743318 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1Cl)=[CH:13][CH:12]=[CH:11][C:10]=2[N+:17]([O-])=O)=[O:5])[CH3:2].[NH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH2:27][CH2:28][NH2:29]>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:29][CH2:28][CH2:27][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[NH2:20])=[CH:13][CH:12]=[CH:11][C:10]=2[NH2:17])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 27505122-(2-Amino-ethyl)-phenylamineHCID 11196760Ethyl 4-chloro-8-nitroquinoline-3-carboxylate

Product 1

HCID 100664748-Amino-4-[2-(2-amino-phenyl)-ethylamino]-quinoline-3-carboxylic acid ethyl esterYield 91%

Procedure

The compound prepared in Example 3 was reacted with 2-(2-amino-phenyl)-ethylamine according to the method as described in Example 4 and the obtained compound was treated as described in Example 14 to prepare the title compound (yield 91%).

Workup

  1. additionthe obtained compound was treated

Sources & evidence

ORD record
ord-6f86e38d92c843668cde44b8a6eadb25
Source dataset
uspto-grants-2006_03
Patent number
US07009053B2

Linked notes

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