Monomethylamine methanol → HCID 59478943, compound
Reaction equation
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[O:12][CH2:13][C:14]1[CH:22]=[CH:21][C:17]([C:18]([NH2:20])=[O:19])=[CH:16][N:15]=1.CN.CO>CO>[NH2:3][O:12][CH2:13][C:14]1[CH:22]=[CH:21][C:17]([C:18]([NH2:20])=[O:19])=[CH:16][N:15]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a suspension of 292 mg of 6-{[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]methyl}nicotinamide in 4.4 ml of methanol was added 0.2 ml of a 40% methyl amine/methanol solution, followed by stirring at room temperature for 1 hour. The reaction solution was concentrated, ethyl acetate was added thereto, and the precipitated crystal was separated by filtration and then concentrated under reduced pressure to obtain 146 mg of 6-[(aminooxy)methyl]nicotinamide.
Workup
- concentrationThe reaction solution was concentrated
- additionethyl acetate was added
- customthe precipitated crystal was separated by filtration
- concentrationconcentrated under reduced pressure
Sources & evidence
- ORD record
- ord-721835e735624f0a83b2d2003a293b4a
- Source dataset
- uspto-grants-2015_10
- Patent number
- US09150541B2
Reaction notes
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