Aluminium lithium hydride → HCID 67983881, compound
Reaction equation
[CH:1]1([C:4]2[O:8][N:7]=[C:6]([CH:9]3[CH2:14][CH2:13][C:12]([CH3:16])([CH3:15])[CH2:11][CH2:10]3)[C:5]=2[C:17](OC)=[O:18])[CH2:3][CH2:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[CH:1]1([C:4]2[O:8][N:7]=[C:6]([CH:9]3[CH2:14][CH2:13][C:12]([CH3:15])([CH3:16])[CH2:11][CH2:10]3)[C:5]=2[CH2:17][OH:18])[CH2:3][CH2:2]1Participants
3
Procedure
(5-cyclopropyl-3-(4,4-dimethylcyclohexyl)isoxazol-4-yl)methanol (I-9F) was prepared by reaction of methyl 5-cyclopropyl-3-(4,4-dimethylcyclohexyl)isoxazole-4-carboxylate and LiAlH4 following the same protocol as described for I-6F. 1H NMR (400 MHz, CDCl3) δ 4.56 (s, 3H), 2.65 (m, 1H), 2.05-1.99 (m, 1H), 1.81-1.75 (m, 4H), 1.52-1.48 (m, 2H), 1.33-1.28 (m, 2H), 1.14-1.10 (m, 2H), 1.04-1.01 (m, 2H), 0.95 (s, 3H), 0.94 (s, 3H). MS m/z 250.1 (M+1).
Sources & evidence
- ORD record
- ord-b9eec4352b6c480b97840dc9030951cf
- Source dataset
- uspto-grants-2015_10