Aluminium lithium hydride → HCID 67984219, compound

Reaction equation

[CH:1]1([C:4]2[O:8][N:7]=[C:6]([CH:9]3[CH2:16][CH2:15][CH2:14][CH2:13][C:10]43[CH2:12][CH2:11]4)[C:5]=2[C:17](O)=[O:18])[CH2:3][CH2:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[CH:1]1([C:4]2[O:8][N:7]=[C:6]([CH:9]3[CH2:16][CH2:15][CH2:14][CH2:13][C:10]43[CH2:12][CH2:11]4)[C:5]=2[CH2:17][OH:18])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 21226445Aluminium lithium hydride

HCID 67983489HCID 67983489, compound

Product 1

HCID 67984219HCID 67984219, compound

Procedure

(5-Cyclopropyl-3-(spiro[2.5]octan-4-yl)isoxazol-4-yl)methanol (I-11L) was prepared by reaction of 5-cyclopropyl-3-(spiro[2.5]octan-4-yl)isoxazole-4-carboxylic acid and LiAlH4 following the same protocol as described for I-6F. MS m/z 248.1 (M+1).

Sources & evidence

ORD record: ord-6befde515433432bb94dd2247df5b653
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09150568B2

Reaction notes

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