ethyl 1-(4-bromophenyl)-5-methyl-1H-pyrazole-4-carboxylate → 1-(5-Cyclopropyl-6-methylpyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid
Reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([C:12]2[CH:17]=[CH:16][C:15](I)=[C:14]([CH3:19])[N:13]=2)[C:10]=1[CH3:11])=[O:5])C.C(O[C:23]([C:25]1[CH:26]=NN(C2C=CC(Br)=CC=2)C=1C)=O)C>>[CH:26]1([C:15]2[CH:16]=[CH:17][C:12]([N:9]3[C:10]([CH3:11])=[C:6]([C:4]([OH:3])=[O:5])[CH:7]=[N:8]3)=[N:13][C:14]=2[CH3:19])[CH2:25][CH2:23]1Participants
3
Procedure
1-(5-Iodo-6-methylpyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester described in Reference Example 31 was used in place of 1-(4-bromophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester in Reference Example 26(2), and reacted and treated in a similar manner to give the titled compound.
Workup
- customreacted