Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | 4-Bromoanisole | HCID 7730 | — |
| Reactant | 1,2-Dibromoethane | HCID 7839 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Product | HCID 178418276 | HCID 178418276 | — |
Reaction Steps
Magnesium (36 g, 1.5 mol), iodine (a few crystals) and THF (1 L) were heated under nitrogen, with stirring, at reflux for 15 min. The mixture was cooled to 20° C., stirring stopped, and 1,2-dibromoethane (2.5 ml) added. After an exothermic reaction was observed (a few min) stirring was restarted which was accompanied by a rise in temperature to 35° C. The mixture was cooled to 20° C. and 4-bromoanisole slowly added over 1 h at 14°-18° C. with cooling. Stirring was continued for 10 min after the addition was complete.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05726315 |
|---|
| Source dataset | uspto-grants-1998_03 |
|---|
| ORD ID | ord-f12406699295447fa245b2a1d83d7703 |
|---|
| Source note | uspto-grants-1998_03 |
|---|
