5,5'-Dithiobis(2-nitrobenzoic Acid) → Diglyceryl silane

HRID 1751195Notes

Reaction equation

HRID 1751195 reaction equation
[Si]([O-])([O-])([O-])[O-].[Na+].[Na+].[Na+].[Na+].C(O[Si:13](OCC)(OCC)OCC)C.CCOP([O:31][C:32]1C=CC([N+]([O-])=O)=CC=1)(OCC)=O.COC1C=C2O[C@@H]3[C@@H](C=CO3)C2=C2OC(=O)C3C(CCC=3C=12)=O.[N+](C1C=CC(SSC2C=CC([N+]([O-])=O)=C(C=2)C(O)=O)=CC=1C(O)=O)([O-])=O.CCC(C[O:96][C:97]([C:110](N(CC[NH+](C)C)C)=[O:111])([C:104]1C=CC=CC=1)C1C=CC=CC=1)CC.[Cl-].[I-].[C:121](SCC[N+](C)(C)C)(=[O:123])[CH3:122]>OCC(CO)O>[CH2:122]([SiH2:13][CH2:104][CH:97]([CH2:110][OH:111])[OH:96])[CH:121]([CH2:32][OH:31])[OH:123]

Participants

9

Reactant 7

HCID 62545,5'-Dithiobis(2-nitrobenzoic Acid)HCID 6517Tetraethoxysilane2×HCID 9395ParaoxonHCID 19153X 100HCID 26051Sodium orthosilicateHCID 74629Acetylthiocholine iodideHCID 186907Aflatoxin B1

Product 1

HCID 102072479Diglyceryl silane

Reagents, catalysts & solvents 1

HCID 753GlycerolSolvent2×

Procedure

Sodium silicate solution (˜14% NaOH, ˜27% SiO2), tetraethylorthosilicate (TEOS, 98%), Dowex 50WX8-100 ion-exchange resin, acetylcholinesterase (AChE, from electrophorus electricus, EC 3.1.1.7), paraoxon, aflatoxin B1 (AfB1, from aspergillus flavus), 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB), carboxymethylcellulose sodium salt (CMC), and Triton X-100 were obtained from Sigma-Aldrich. Anhydrous glycerol and acetylthiocholine iodide (ATCh) were purchased from Fluka BioChemika Ultra (UK). Diglyceryl silane (DGS) was synthesized in our lab using by transesterification of TEOS with anhydrous glycerol as described in detail elsewhere.26 Polyvinylamine (PVAm; 1.5 MDa) was obtained from BASF (Mississauga, Canada), as a gift. Mead brand cardboard paper substrate with a white hydrophobic clay coating (Manufactured by Hilroy, Toronto, Canada) was purchased from McMaster University Bookstore. Distilled deionized water (ddH2O) was obtained from a Milli-Q Synthesis A10 water purification system. All other reagents were of analytical grade.

Workup

  1. distillationDistilled
  2. customwas obtained from a Milli-Q Synthesis A10 water purification system

Sources & evidence

ORD record
ord-3137cf000eea4e9dbe6e190e4e795100
Source dataset
uspto-grants-2015_10
Patent number
US09157109B2

Reaction notes

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