Pyridine → N-[3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl]-2,5-difluorobenzenesulfonamide

HRID 175170Notes

Reaction equation

HRID 175170 reaction equation
[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:17]3[c:18]([F:24])[c:19]([NH2:20])[cH:21][cH:22][cH:23]3)[n:10][c:11]([C:13]([CH3:14])([CH3:15])[CH3:16])[s:12]2)[n:7]1.[Cl:43][CH2:44][Cl:45].[F:31][c:32]1[c:33]([S:39](=[O:40])(=[O:41])[Cl:42])[cH:34][c:35]([F:38])[cH:36][cH:37]1.[cH:25]1[cH:26][cH:27][n:28][cH:29][cH:30]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:17]3[c:18]([F:24])[c:19]([NH:20][S:39]([c:33]4[c:32]([F:31])[cH:37][cH:36][c:35]([F:38])[cH:34]4)(=[O:40])=[O:41])[cH:21][cH:22][cH:23]3)[n:10][c:11]([C:13]([CH3:14])([CH3:15])[CH3:16])[s:12]2)[n:7]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 27369112,5-Difluorobenzenesulfonyl chlorideHCID 579898453-(2-Tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluoroaniline

Product 1

HCID 44516823N-[3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl]-2,5-difluorobenzenesulfonamide

Sources & evidence

ORD record
ord-6428ccba6eac443ea1c289f79cdd40d4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…