HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 6-Amino-5-bromopyridine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 2-Amino-5-cyanopyridine | HCID 818260 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6-Amino-5-bromopyridine-3-carbonitrile | HCID 1491250 | 49.5% |
Reaction Steps
Br2 (0.52 mL, 0.01 mol) was added to a solution of 6-aminonicotinonitrile (1.1901 g, 0.01 mol) in AcOH (10 mL) at room temperature. The mixture was stirred at room temperature for 2 h. Then the mixture was concentrated and the residue was purified by flash column chromatography to give the title product (980.0 mg, 49%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09162980B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-3c3f73d384034bff9d09d4b9052641f3 |
| Source note | uspto-grants-2015_10 |