3-Chloro-2-iodo-5-nitropyridine → 3-Chloro-5-nitropicolinonitrile
Reaction equation
[Cu]([C:4]#[N:5])C#N.[Cl:6][C:7]1[C:8](I)=[N:9][CH:10]=[C:11]([N+:13]([O-:15])=[O:14])[CH:12]=1>C(#N)C>[Cl:6][C:7]1[C:8]([C:4]#[N:5])=[N:9][CH:10]=[C:11]([N+:13]([O-:15])=[O:14])[CH:12]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
A suspension of copper cyanide (7 g) and 3-chloro-2-iodo-5-nitro-pyridine (7 g) in acetonitrile (200 mL) was heated to 80° C. within 1 hour and stirred at 80° C. for 5 hours. The solvent was evaporated and the residue was filtered in ethyl acetate over silicon dioxide gave 3-chloro-2-cyano-5-nitro-pyridine (4.26 g).
Workup
- customThe solvent was evaporated
- filtrationthe residue was filtered in ethyl acetate over silicon dioxide
Sources & evidence
- ORD record
- ord-425a9c3c12734dd9bc2e4162542bae20
- Source dataset
- uspto-grants-2015_10
- Patent number
- US09162986B2
Reaction notes
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