Ethyl bromoacetate → HCID 90093751, compound

Reaction equation

[CH:1]([C:4]1[NH:8][N:7]=[CH:6][CH:5]=1)([CH3:3])[CH3:2].Br[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]>>[CH2:14]([O:13][C:11](=[O:12])[CH2:10][N:8]1[C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=[N:7]1)[CH3:15]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 122513813-(Propan-2-YL)-1H-pyrazole

Product 1

HCID 90093751HCID 90093751, compoundYield 6%

Procedure

Prepared according to the method described for Preparation 75 using 5-isopropyl-1H-pyrazole and ethyl bromoacetate. The residue was purified using silica gel column chromatography eluting with 4:1 hexane:EtOAc. The title compound was isolated as the lower running minor product in 6% yield, and taken directly on to the next step.

Workup

customPrepared
customThe residue was purified
washeluting with 4:1 hexane

Sources & evidence

ORD record: ord-d7ba6912db9b4940affd182c946499f4
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09163021B2

Reaction notes

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