HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-Bromo-4-(cyclopropylmethoxy)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 4-Bromophenol | HCID 7808 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (Chloromethyl)cyclopropane | HCID 80013 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Bromo-4-(cyclopropylmethoxy)benzene | HCID 15625752 | — |
Reaction Conditions
| Temperature | 80 °C |
|---|
Reaction Steps
5.0 g (28.9 mmol) 4-bromophenol, 3.93 g (43.4 mmol) (chloromethyl)cyclopropane and 7.99 g (57.8 mmol) K2CO3 are added to 10 mL DMF and stirred at 80° C. over night. Afterwards the reaction mixture is diluted with water and extracted with DCM. The organic layer is dried over MgSO4 and the solvent is removed in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09169205B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-c5898888703d450b96cc0836bd4c9444 |
| Source note | uspto-grants-2015_10 |