HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Hydroxyiminomethyl)quinolin-8-ol → 2-(Aminomethyl)quinolin-8-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Hydroxyiminomethyl)quinolin-8-ol | HCID 604733 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(Aminomethyl)quinolin-8-ol | HCID 599967 | 82% |
Reaction Steps
8-Hydroxy-quinoline-2-carboxaldehyde oxime D1 (167 mg, 0.888 mmol) and MeOH (50 mL) was treated under hydrogenolysis conditions (atmospheric H2, catalytic 10% Pd/carbon) at RT. After 4 h, the catalyst was filtered off and the volatiles removed which afforded 2-aminomethyl-quinolin-8-ol E1 as a light brown solid (126 mg, 82%); spectral data of this compound are given in Table 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09169211B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-a2276ad63db24b05986919f8d7dc5e77 |
| Source note | uspto-grants-2015_10 |