HCID 86257708, compound → 1-(4-fluorophenyl)-1H-pyrazol-4-amine
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([N+:13]([O-])=O)[CH:10]=[N:9]2)=[CH:4][CH:3]=1>CCO.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([NH2:13])[CH:10]=[N:9]2)=[CH:6][CH:7]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A mixture of 1-(4-fluorophenyl)-4-nitropyrazole (0.820 g, 3.96 mmol) and 10% Pd/C (0.133 g, 50% wet by wt) in EtOH (50 mL) was fitted onto a Parr apparatus and agitated under H2 at 40 psi for 40 min. The reaction mixture was then filtered through filter paper. The filtrate was collected and concentrated in vacuo to give 1-(4-fluorophenyl)pyrazol-4-amine as an oil (0.675 g, 96%).
Workup
- customwas fitted onto a Parr apparatus
- filtrationThe reaction mixture was then filtered
- filtrationthrough filter paper
- customThe filtrate was collected
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-a18390c029154e59af9a3eb968c86735
- Source dataset
- uspto-grants-2015_10
- Patent number
- US09169248B2
Reaction notes
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