Acetic Anhydride → N-(4-Fluoro-2-methylphenyl)acetamide
Reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.[F:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[C:11]([CH3:16])[CH:10]=1>C(Cl)(Cl)Cl>[F:8][C:9]1[CH:15]=[CH:14][C:12]([NH:13][C:5](=[O:7])[CH3:6])=[C:11]([CH3:16])[CH:10]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Acetic anhydride (17.7 ml, 0.19 mol) was dropwise added to 4-fluoro-2-methylaniline (234 g, 0.19 mol). The solidified reaction mixture was dissolved in chloroform, washed with an aqueous saturated sodium hydrogencarbonate solution and saturated brine, then dried over anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the residue was dried with a vacuum pump to obtain the entitled compound (31.7 g, 99%) as a pale red solid.
Workup
- customThe solidified reaction mixture
- washwashed with an aqueous saturated sodium hydrogencarbonate solution and saturated brine
- dry with materialdried over anhydrous sodium sulfate
- customThe solvent was evaporated away under reduced pressure
- customthe residue was dried with a vacuum pump
Sources & evidence
- ORD record
- ord-b28a3fb55f434213817c419a6f86b40a
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07737166B2
Reaction notes
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