2-Chloroacetophenone → 3Chloro-2-methyl-7-phenacylpyrrolo-[2,3-b]pyridinehydrochloride
Reaction equation
[Cl:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]=1[CH3:11].Cl[CH2:13][C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:15]>CC#N>[ClH:1].[Cl:1][C:2]1[C:10]2[C:5]([N:6]([CH2:13][C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[O:15])[CH:7]=[CH:8][CH:9]=2)=[N:4][C:3]=1[CH3:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 200 mg (1.2 mmol) of 3-chloro-2-methyl pyrrolo-[2,3-b]pyridine and 204 mg (1,3 mmol) of 2-chloroacetophenon in 10 ml of CH3CN was refluxed for 48 h. The reaction mixture was cooled to room temperature and stirred for one hour. The precipitate was filtered off to give 260 mg (67%) of 3chloro-2-methyl-7-phenacylpyrrolo-[2,3-b]pyridinehydrochloride.