2-Chloro-1-(2,4-difluorophenyl)ethanone → HCID 21743851, compound
Reaction equation
[C:1]([CH2:3][C:4]1[C:12]2[C:7](=[N:8][CH:9]=[C:10]([F:13])[CH:11]=2)[NH:6][C:5]=1[CH3:14])#[N:2].[F:15][C:16]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:17]=1[C:18](=[O:21])[CH2:19][Cl:20]>C(#N)C>[ClH:20].[C:1]([CH2:3][C:4]1[C:12]2[C:7]([N:8]([CH:19]([CH2:19][C:18]([C:17]3[CH:22]=[CH:23][C:24]([F:26])=[CH:25][C:16]=3[F:15])=[O:21])[C:18]([C:17]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:16]=3)=[O:21])[CH:9]=[C:10]([F:13])[CH:11]=2)=[N:6][C:5]=1[CH3:14])#[N:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The title compound was prepared from 3-(cyanomethyl)-5-fluoro-2-methylpyrrolo[2,3-b]pyridine (10 mg, 0.053 mmol) and 2,4-difluorophenacyl chloride (128 mg, 0.67 mmol) in acetonitrile (0.2 ml) in the same fashion as described in example 71; yield 16 mg (80%).