Thionyl Chloride → 5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthylacetyl chloride

HRID 1756417

Reaction equation

HRID 1756417 reaction equation
[CH3:1][C:2]1([CH3:18])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([CH2:14][C:15](O)=[O:16])[CH:5]=[CH:4][C:3]1=2.S(Cl)([Cl:21])=O>>[CH3:1][C:2]1([CH3:18])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([CH2:14][C:15]([Cl:21])=[O:16])[CH:5]=[CH:4][C:3]1=2

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 181779322-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)acetic acid

Product 1

HCID 214744835,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthylacetyl chloride

Procedure

6.6 g (26.8 mmol) of 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylacetic acid and 20 ml of thionyl chloride are heated to reflux until gaseous evolution has ceased. The mixture is evaporated to dryness and 7.1 g (100%) of the crude acid chloride are obtained, which product is used for the next step of the synthesis without further treatment.

Workup

  1. temperatureto reflux until gaseous evolution
  2. customThe mixture is evaporated to dryness and 7.1 g (100%) of the crude acid chloride
  3. customare obtained
  4. customwhich product is used for the next step of the synthesis without further treatment

Sources & evidence

ORD record
ord-1e13343e001945cba027dd7b756cd264
Source dataset
uspto-grants-1995_08
Patent number
US05439925

Linked notes

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